Share on FacebookTweet about this on TwitterShare on Google+Share on RedditShare on StumbleUponcomment this pageEmail this to someonePin on PinterestShare on LinkedInDigg thisShare on Tumblrdelicious this pagetechnorati this pagefark this page

“I share, therfore i am!” – What is the connection between Social Networks and Being Lonely? It’s a problem that seems to be growing just as fast as technology is advancing. The question that doctors and psychiatrists are pondering over is ‘as we expect more from technology, do we expect less from each other?’

In a world where time is money, in which our surrounding heavily pressure us to achieve more, our social life becomes tainted and more demanding than ever before.

Social networks aren’t just changing what we are doing, but who we are. We are expecting more from technology and less from each other.

Changes in the brain’s white matter have been seen before in psychiatric disorders, and demyelinating disorders like multiple sclerosis have also had an association with depression. Recently, myelin changes were also seen in very young animals or adolescents responding to environmental changes.

But Karen Dietz, lead author on the study published online in the journal Nature Neuroscience, said: ‘This research reveals for the first time a role for myelin in adult psychiatric disorders.

‘It demonstrates that plasticity in the brain is not restricted to neurons, but actively occurs in glial cells, such as the oligodendrocytes, which produce myelin.’


Myelin is a crucial fatty material that wraps the axons of neurons, helping them signal effectively. Normal nerve function is lost in demyelinating disorders, such as MS and the rare, fatal childhood disease, Krabbe’s disease.

The paper revealed how the stress of social isolation disrupts the sequence in which the myelin-making cells, the oligodendrocytes, are formed.

In an experiment, adult mice (normally social animals) were isolated for eight weeks to induce a depressive-like state, before being introduced to a mouse they hadn’t met before.

While mice are normally highly motivated to be social, those who had been socially isolated did not show any interest in interacting with the new mouse, a typical model of social avoidance and withdrawal.

But we shouldn’t lose any sleep over our diminishing brain power, as by the time it becomes a real problem technology will have found a solution making natural selection obsolete, the researchers say in a paper published today in Cell Press journal Trends in Genetics.

Brain tissue analysis of the isolated animals revealed significantly lower than normal levels of gene transcription for oligodendrocyte cells in the prefrontal cortex, a brain region responsible for emotional and cognitive behavior.

‘This research provides the first explanation of the mechanism behind how this brain plasticity occurs showing how this change in the level of social interaction of the adult animal resulted in changes in oligodendrocytes,’ said Dr Dietz, a research scientist in the Department of Pharmacology and Toxicology in the UB School of Medicine and Biomedical Sciences.


The key change was that cellular nuclei in the prefrontal cortex contained less heterochromatin, a tightly packed form of DNA material, which is unavailable for gene expression.

‘This process of DNA compaction is what signifies that the oligodendrocytes have matured, allowing them to produce normal amounts of myelin,’ Dr Dietz said. ‘We have observed in socially isolated animals that there isn’t as much compaction, and the oligodendrocytes look more immature.

‘As adults age, normally, you would see more compaction, but when social isolation interferes, there’s less compaction and therefore, less myelin being made.’

She added, however, that the research also showed that myelin production went back to normal after a period of social integration, suggesting that environmental intervention was sufficient to reverse the negative consequences of adult social isolation.

Dr Dietz said the findings have implications for future questions regarding MS and other myelin disorders.

‘This research suggests that maybe recovery from an MS episode might be enhanced by social interaction,’ she says. ‘This opens another avenue of investigation of how mood and myelin disorders may interact with one another.’

At a deeper level, though, loneliness research forces us to acknowledge our own extraordinary malleability in the face of social forces. This susceptibility is both terrifying and exhilarating.


(h/t: Daily Mail)

Share on FacebookTweet about this on TwitterShare on Google+Share on RedditShare on StumbleUponcomment this pageEmail this to someonePin on PinterestShare on LinkedInDigg thisShare on Tumblrdelicious this pagetechnorati this pagefark this page

It’s Thanksgiving. You weren’t aware of that, were you? You just thought you had the day off work because the world was a nice place. The fact…

funny videos

Burnt turkeys, cranberry sauce all over the kitchen floor, that sense of bloating that can only come after you’ve eaten your bodyweight in home cooked food, it’s…

funny pics

You may or you may not (if not then shame on you) know or have come across the “I have no idea what I’m doing” meme which,…


There have been A LOT of Star Wars: The Force Awakens parodies, but none of them have included real jets and members of the US Navy. Until…


Dubbed “Cat Island”, Aoshima in southern Japan is overrun by feral cats, who have practically overtaken the small fishing village and outnumber the human inhabitants six to…


Everyone knows is a big NO-NO to beat your kids, under any circumstances, it’s totally unacceptable, but that’s exactly what you first think is happening here as…


Amazon founder Jeff Bezos’ aerospace company Blue Origin successfully launched and landed a reusable space rocket called New Shepard. Space rockets are historically expendable but this could…


Thanksgiving is a time to sit around the table, come together as a family, and of course, argue and fight. It’s an inevitability as various generations come…


You might not immediately think of crayon as a material to sculpt with, but that’s what artist Hoang Tran uses to create miniature pop culture figures. Tran…


In this rather brilliant video from YouTubers Pistol Shrimps Peeta, the all-important character from The Hunger Games franchise, is replaced with some pita bread. Gone is actor…


Cats and dogs like nothing more than curling up on the couch and chilling the heck out. Just like we do they like to take away the…


OK boyfriends of the world, you need to up your game. Jack Harries has shown you all up with this birthday present for his girlfriend Ella. After…